输入肠道的甲治疗出血性辐射诱导的前列病:疗效和安全性
Darina Kohoutova1, Ana Wilson1,2, Caroline Gee1
1The Royal Marsden Hospital NHS Foundation Trust, London, UK.
概括
肠内甲素有效地治疗放射治疗诱导的出血性前列病 (RHP),显著减少直肠出血并改善内镜外观. 这种安全的治疗方法为管理盆腔放射治疗的这种常见并发症提供了一个可行的选择.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 辐射疗法 辐射疗法
背景情况:
- 盆腔放射治疗可能会对周围器官产生剂量依赖的毒性.
- 放射治疗诱导的出血性直肠病 (RHP) 是一种严重的并发症,导致直肠出血和降低生活质量.
- 现有的RHP治疗方法在有效性和安全性方面存在局限性.
研究的目的:
- 为了前性地评估内甲治疗RHP的疗效和安全性.
- 评估甲素治疗对直肠出血严重程度和内镜检查结果的影响.
- 为了确定与内甲治疗相关的并发症率.
主要方法:
- 一项前性研究招募了患有RHP的成年患者.
- 患者接受了内5%的甲素治疗.
- 在治疗前后记录了直肠出血得分,内镜外观,血红蛋白水平和并发症.
主要成果:
- 19名患者 (平均年龄75岁) 平均接受了1.7次甲治疗.
- 在直肠出血得分 (中位数6至2,p<0.001) 和内镜外观 (中位数3至1,p<0.001) 中观察到显著改善.
- 血红蛋白水平显著增加 (平均为110至123g/L,p=0.022),并发症率为5% (直阴道).
结论:
- 肠内甲治疗是一种有效的疗法,用于放射疗法诱导的出血性前列病.
- 这种治疗方法表现出良好的安全性,并发症率低.
- 正式灌为管理RHP提供了一种有价值的治疗选择.
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