基于质谱的蛋白质组学对有或没有口腔疾病的狗进行分析:系统性审查
Paras Ahmad1, Walter L Siqueira2
1College of Dentistry, University of Saskatchewan, 105 Wiggins Road, Saskatoon, SK, S7N 5E5, Canada.
BMC oral health
|March 23, 2024
概括
狗的口腔生物流体蛋白质学揭示了健康和患病的狗之间不同的签名. 这项研究有助于理解犬口腔疾病和跨物种牙科研究.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 蛋白质组学是指蛋白质组学.
- 生物信息学是一种生物信息学.
背景情况:
- 狗的口腔生物流体中明确的蛋白质组学概况对于诊断和治疗狗口腔疾病至关重要.
- 了解这些概况有助于跨物种的翻译性研究在牙科和医学.
研究的目的:
- 系统地审查和比较健康狗与口腔疾病的狗的口腔生物流体蛋白质组概况.
- 为了确定这些群体之间的蛋白质特征的相似性和差异.
主要方法:
- 对PubMed,科学网络和Scopus数据库进行系统审查.
- 基因和基因组的基因本体学和京都百科全书 丰富的蛋白质的通路分析.
- 使用Joanna Briggs Institute工具进行蛋白质与蛋白质相互作用分析和偏差风险评估.
主要成果:
- 健康的狗表现出5451种蛋白质,其中137种丰富的蛋白质与"先天免疫反应"有关.
- 患病的狗表现出6470种蛋白质,具有明显的关联,如"对细菌的防御反应" (牙周病) 和"转录的积极调节" (口腔瘤).
- 确定了重要的蛋白质集群,突出了不同的分子配置文件;所有纳入的研究都有低偏差风险.
结论:
- 在健康和患病的狗之间,口腔生物流体蛋白质学存在显著差异.
- 动物蛋白质学和生物信息学的整合为口腔健康的跨物种研究提供了有价值的方法.
- 需要进一步验证,以应对结果解释方面的挑战.
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