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肥胖是痴呆症发展中的肥胖悖论的一部分:基于人口的队列研究的证据
Junhan Zhang1,2, Xiaona Na1,2, Zhihui Li1,2
1Vanke School of Public Health, Tsinghua University, Beijing, China.
BMC medicine
|March 23, 2024
概括
肥胖和肥胖症增加了痴呆症的风险和早期发病,肥胖症增加了痴呆症的风险和早期发病.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 肥胖症和肥胖症的同时发生,是一种越来越令人担忧的问题.
- 它对痴呆风险和发病的影响仍未得到充分研究.
研究的目的:
- 为了调查sarcopenic肥胖,sarcopenia,肥胖和痴呆风险和发病之间的联系.
- 探索性别和遗传因素 (多基因风险评分) 对这些关联的影响.
- 检查与大脑成像参数的关系以及慢性疾病的调解作用.
主要方法:
- 利用了来自60-69岁的208,867名参与者的英国生物库数据.
- 使用Cox比例危险模型进行风险评估和限制平均生存时间模型进行发病.
- 按性别和痴呆多基因风险评分 (PRS) 进行分层分析;用于脑成像的线性回归;用于慢性疾病的调解分析.
主要成果:
- 肥胖症显著增加了痴呆症的风险 (HR女性: 1.424,男性: 1.989) 和晚期发病 (女性: 0.109年,男性: 0.511年).
- 肉类也增加了痴呆症的风险 (HR女性: 1.323,男性: 2.144) 和晚期发病.
- 肥胖对痴呆风险和发病的影响因性别和PRS而异;观察到与大脑变化的关联以及慢性疾病的调解.
结论:
- 麻性肥胖和麻症与更高的痴呆风险和早期发病有关.
- 肥胖对痴呆风险的影响是由性别和遗传倾向调节的.
- 研究结果突出了人体组成,遗传学和痴呆症慢性疾病的复杂相互作用.
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