相关实验视频
Updated: May 3, 2026
10:35
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
18.2K
在儿科瘤和其他固体瘤的手术内放射疗法
Brianna Conte1, Dana L Casey2, Kathryn R Tringale3
1University of Miami Miller School of Medicine, Miami, Florida, USA.
Pediatric blood & cancer
|March 23, 2024
概括
术内放射治疗 (IORT) 对儿科固体瘤有效,局部失效率低于25%,毒性可接受. 这种技术为儿童的挑战性病例提供了一个安全的选择.
科学领域:
- 儿科瘤学 儿科瘤学
- 辐射瘤学 辐射瘤学
- 手术瘤学手术瘤学
背景情况:
- 术内辐射疗法 (IORT) 是一种专门的辐射技术,在手术期间向瘤床输送高剂量的辐射.
- 由于患者的年龄和瘤生物学,儿科固体瘤 (ST) 在治疗中存在独特的挑战.
- 评估IORT在儿科ST中的疗效和安全性对于优化治疗策略至关重要.
研究的目的:
- 在患有固体瘤 (ST) 的儿科患者中,评估手术内放射治疗 (IORT) 后局部衰竭 (LF) 率.
- 在这个儿科群体中评估与IORT相关的毒性概况.
- 确定IORT在具有挑战性的儿科ST病例中进行局部控制的整体安全性和有效性.
主要方法:
- 一个回顾性分析的96名儿科患者 (108个申请) 在一个机构在1995年至2022年期间接受ST的IORT治疗.
- 用累积发病率函数计算局部衰竭 (LF),用卡普兰-梅尔法确定整体存活率 (OS).
- 收集的数据包括患者人口统计,瘤组织学,先前的治疗,IORT剂量,治疗区域,LF和毒性.
主要成果:
- 在IORT后2年,局部衰竭 (LF) 的累积发病率为17%,在IORT后5年为23%.
- 毒性是可以接受的,在16%的患者中观察到与IORT潜在相关的术后并发症.
- 常见的组织学包括狂肌肉瘤,尤宁肉瘤和威尔姆斯瘤;由于困难的情况,54%的人接受了前期IORT治疗.
结论:
- 术内辐射疗法 (IORT) 在实现儿科固体瘤 (ST) 的局部控制方面表现出有效性,只有不到四分之一的患者经历了局部失败.
- 该研究强调IORT是一种安全有效的技术,特别是在具有挑战性瘤呈现的儿科患者中.
- 这一分析为了解IORT在儿科瘤学中的长期结果做出了重大贡献.
相关概念视频
02:49Cancer Therapies
8.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.5K
01:27Tumor Immunotherapy
2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
722
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
722