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狄米丁丁 - - 对儿童的最小毒剂量是否过于严格?
Michal Čečrle1,2, Daniela Pelclová1, Navrátil Tomáš3
1Toxicological Information Center, Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Basic & clinical pharmacology & toxicology
|March 23, 2024
概括
儿童意外的二甲中毒很少引起严重的症状. 对于儿童来说,最小的有毒剂量是0.5mg/kg,大多数病例呈现轻度,自我解决的症状.
科学领域:
- 药理学 药理学是指药理学的学科.
- 儿科毒理学 儿科毒理学
- 过敏治疗方法 过敏治疗方法
背景情况:
- 狄米丁丁是一种用于过敏症的镇静抗组胺药物.
- 对于儿童的dimetindene,有有限的毒性数据.
- 由于小儿科患者的二美丁丁过量服用,没有确定的住院门.
研究的目的:
- 为了确定在儿童中潜在有毒的dimetindene剂量.
- 为了确定在儿科患者中摄入dimetindene的最低毒性剂量.
主要方法:
- 追溯分析了139份儿科医院出院报告,这些报告是由于摄入了二甲的.
- 由于摄入不确定的原因,23份报告被排除在外,剩下116个案例进行分析.
- 计算剂量以每公斤体重 (B.W.) 的毫克. 根据报告的摄入量.
主要成果:
- 在分析的116例病例中,75%的儿童仍然没有症状.
- 25%的儿童经历了轻微的,自我解决的中毒症状.
- 确定二甲丁烯的最小毒性剂量为0.5mg/kg体重.
结论:
- 儿童意外的二甲中毒一般具有良好的预后.
- 住院儿童被观察最长24小时,不需要特殊治疗.
- 确定的最小毒性剂量为儿童患者管理二甲过量剂量的指导方针.
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