听力损失的环境风险因素,保护因素和生物标志物:一个总体审查
Xianpeng Xu1,2, Yiru Liao1,2, Lihong Zhang1,2
1Department of Otorhinolaryngology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
概括
这一综合性审查发现了听力损失与类风湿性关节炎,艾滋病毒,糖尿病,吸烟和噪音暴露等因素之间的强烈关联. 它还强调了听力健康的潜在生物标志物和保护元素.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 环境健康 环境健康
- 流行病学 流行病学
背景情况:
- 听力损失 (HL) 是一个重要的全球健康问题,具有复杂的病因.
- 环境因素和生物标志物在HL的发展和进展中起着至关重要的作用.
- 对这些因素的全面了解对于有效的预防和管理策略至关重要.
研究的目的:
- 对观察性研究的元分析进行总体审查.
- 调查与听力损失相关的潜在环境风险因素,保护因素和生物标志物.
- 建立这些关联的证据等级.
主要方法:
- 在Embase,PubMed,Cochrane图书馆和Web of Science数据库中搜索到2023年6月1日.
- 包括观察性研究的元分析,检查HL与环境因素或生物标志物之间的关联.
- 计算了总结效果估计,置信区间,并评估了异质性和偏差.
主要成果:
- 包括从 9211 获取的 60 个符合条件的文章,确定 47 个风险/保护因素和 46 个生物标志物.
- 有令人信服的证据 (I类) 将类风湿性关节炎 (RA) 和增加身高与HL联系起来.
- 强烈暗示性证据 (II类) 将艾滋病毒,糖尿病,累积噪声暴露 (CNE),吸烟,先天性CMV感染等与HL相关联.
结论:
- 风湿性关节炎,增高,艾滋病毒,糖尿病,CNE,吸烟,先天性CMV感染和噪音暴露与听力损失有很强的关联.
- 该研究确定了许多需要进一步调查的环境因素和生物标志物.
- 这些发现强调了听力损失的多因素性质,并为公共卫生倡议提供了信息.
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