相关实验视频

Updated: Jun 30, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

基于高临床翻译纳米系统的综合战略,用于对三阴性乳腺癌的可编程免疫治疗

Meng Meng^1,2, Jiayan Wu^1,2, Yuanji Feng³

¹Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

Advanced materials (Deerfield Beach, Fla.)

|March 23, 2024

概括

这项研究开发了一种新型纳米系统 (FeSH NP) 用于三阴性乳腺癌 (TNBC) 的协同光热免疫疗法. 该疗法有效地对抗免疫冷瘤的原发性瘤,复发和转移.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

三阴性乳腺癌 (TNBC) 是一种免疫学上"冷"的瘤,对单一疗法有耐药性,复发和转移率高.
有效的治疗需要重新编程瘤微环境 (TME) 从"冷"到"热",以提高治疗效果.

研究的目的:

设计和制造一个多功能纳米系统 (FeSH NP) 用于TNBC的协同光热免疫疗法.
评估光热疗法 (PTT),TME重编程和抗PD-L1抗体治疗的联合疗效.

主要方法:

制造FeSHNP,集成PTT和沙尔维亚诺酸B (SAB) 的金属多协调复合物作为免疫调节剂.
使用光热/光声双模式成像用于指导.
通过PTT诱导免疫细胞死亡 (ICD),并释放SAB来抑制TGF-β,并在TME中调节PD-L1.
结合FeSH NPs治疗与抗PD-L1抗体治疗.

主要成果:

在TNBC中FeSHNP介导的PTT诱导的ICD.
SAB释放有效地重塑了TME,抑制了TGF-β,并调节了PD-L1.1.
组合疗法协同消除了原发性瘤,复发和转移.
FeSH NPs表现出良好的生物安全性.

结论:

开发的FeSH NP为像TNBC这样的免疫冷瘤的编程疗法提供了一个有希望的战略.
这种多功能纳米系统可以实现协同光热免疫疗法,克服TNBC耐药性并改善治疗结果.
这种方法具有很高的临床转化潜力,可用于全面的癌症治疗.

关键词:

免疫检查点封锁封锁可编程的光热免疫疗法转化生长因子β的转化生长因子β.三重阴性乳腺癌是什么瘤微环境重编程

更多相关视频

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...