在前列腺癌的老年男性中,长期的雄激素剥夺疗法的认知效应
Denise Pergolizzi1, Kathleen R Flaherty2, Rebecca M Saracino2
1School of Medicine and Health Sciences, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Psycho-oncology
|March 23, 2024
概括
长期的雄激素剥夺疗法 (ADT) 可能会对前列腺癌 (PCa) 的老年男性的语言学习和回忆等认知功能产生负面影响. 与考虑ADT的患者讨论潜在的认知影响.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
背景情况:
- 安卓素剥夺疗法 (ADT) 是前列腺癌 (PCa) 的标准治疗方法.
- 越来越多的男性正在接受长期的ADT治疗,但其对认知的影响,特别是对老年人来说,尚不清楚.
- 这项研究调查了ADT对65岁及以上的PCa男性认知的影响.
研究的目的:
- 评估长期ADT暴露对PCa的老年男性 (≥65岁) 的认知影响.
- 为了比较ADT暴露和ADT未暴露组之间的神经心理测试表现.
主要方法:
- 一组133名65岁以上的男性患有PCa被分为两组:暴露于ADT (1-3岁) 和未暴露于ADT.
- 进行神经心理测试以评估认知领域,包括口头学习,口头回忆和视觉空间构造.
- 计算效应大小 (科恩的d) 来量化群体差异,并根据年龄和教育程度进行调整.
主要成果:
- 与未接触ADT的组相比,暴露ADT的组在口头学习和口头回忆方面表现明显较低.
- 在暴露于ADT的组中,在视觉空间结构中也观察到潜在的负面影响.
- 这些认知差异甚至在控制年龄和教育后仍然存在.
结论:
- 长期的ADT暴露与PCa的老年男性的语言学习,语言回忆和潜在的视觉空间能力受损有关.
- 医疗保健提供者应与老年患者讨论ADT潜在的认知副作用.
- 需要进一步的研究,以充分阐明ADT的长期认知后果.
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