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解开并量化并发性混合神经退行性病理的相对认知影响

Carolina Maldonado-Díaz¹, Satomi Hiya¹, Raquel T Yokoda¹

¹Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, Annenberg Building, 15.238, 1468 Madison Avenue, New York, NY, 10029, USA.

Acta neuropathologica

|March 23, 2024

概括

多种神经退行性疾病经常同时存在,影响认知. 这就是阿尔茨海默病的原因.

科学领域:

神经病理学神经病理学
神经退行性疾病神经退行性疾病
认知科学认知科学

背景情况:

神经退行性病理的同时存在,如阿尔茨海默氏症神经病理变化 (ADNC),勒维体病 (LBD),边缘主导的与年龄有关的TDP-43脑病变神经病理变化 (LATE-NC) 和脑血管疾病 (CVD) 是常见的.
每种病理对混合病理病例认知衰退的具体贡献仍然不太清楚.

研究的目的:

研究同时发生的神经退行性病理对认知功能的相对影响.
为了确定特定的神经病理和认知表现之间的相关性.

主要方法:

来自国家阿尔茨海默氏症协调中心数据库的大型队列 (6,262名受试者) 的分析.
多变量逻辑回归调整为年龄,性别和教育水平.
使用临床痴呆评分 (CDR®) 和迷你精神状态检查 (MMSE) 评估认知表现.

主要成果:

每个人病理总数较多与认知表现较差相关 (CDR®较高,MMSE较低).
ADNC,LBD,LATE-NC,CVD,海马硬化症,皮克病和FTLD-TDP独立地对认知产生了重大影响.
ADNC影响了所有认知领域; LBD影响了注意力,处理速度和语言; LATE-NC影响了逻辑记忆和语言; CVD具有可变的影响.
ADNC,LBD和增加的病理负担与APOE ε4相关,而ADNC和病理负担与APOE ε2.2相反相关.

结论:

个体和综合的神经退行性病理显著影响认知功能.
了解这些复杂的相互作用对于开发有针对性的生物标志物和针对痴呆症的个性化治疗方法至关重要.

关键词:

与年龄相关的病症.阿尔茨海默病的神经病理变化这是一个CDRCDR.脑血管疾病是脑血管疾病.皮层骨干退行症皮层骨干退行前側葉痴呆症前側葉痴呆症利维体痴呆症 (Lewy体痴呆症) 是一种疾病.临主导的与年龄相关的TDP-43脑病变.这是一个MMSE.挑选疾病选择疾病渐进性的超核性.

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