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在患有过度活跃膀的患者中,对Vibegron的实践坚持和坚持:回顾性索赔分析
Benjamin Chastek1, Adam Carrera2, Christina Landis1
1Optum, Eden Prairie, MN, USA.
Advances in therapy
|March 23, 2024
概括
近一半的患者开始使用维贝格伦治疗过活性膀 (OAB),表现出良好的坚持. 处方实践,而不是患者因素,影响了对vibegron治疗的坚持和坚持.
科学领域:
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 现实世界的证据.
背景情况:
- 维贝格龙是一种β3-上腺素受体激动剂,已被批准用于治疗过度活性膀 (OAB).
- 现实世界的坚持和持久性数据对于了解OAB患者治疗有效性至关重要.
研究的目的:
- 评估在OAB患者中使用vibegron的真实世界的坚持和持久率.
- 确定与vibegron坚持和持久性相关的人口和临床因素.
主要方法:
- 使用Optum研究数据库进行的回顾性研究 (2021年4月至2022年8月).
- 坚持性定义为覆盖日数比例 (PDC) ≥80%;持续性以停药前的几天来衡量.
- 多变量模型分析了与坚持和坚持相关的因素.
主要成果:
- 几乎一半 (49.2%) 开始使用维贝格伦的患者仍然坚持使用 (PDC ≥80%).
- 更高的坚持和持久性与更大的初始日供应和更高的基线药物计数有关.
- 较高的指数copay (>45美元) 与更高的停药率有关.
结论:
- 在OAB患者中,对vibegron的实际守率接近50%.
- 处方实践,如最初几天的供应和基线药物计数,显著影响坚持和持续性.
- 开始后4-5个月的随访可能会优化vibegron治疗结果.
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