相关实验视频

Updated: Jun 30, 2025

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

在DSS诱导的大肠炎中探索Anastatica hierochuntica精油的治疗潜力

Abdelrahim Alqudah¹, Esam Qnais², Omar Gammoh³

¹Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, Jordan. Abdelrahim@hu.edu.jo.

Inflammopharmacology

|March 23, 2024

概括

在小鼠实验中,Anastatica hierochuntica精油 (EOAH) 有效地保护了对实验性大肠炎的保护. EOAH减少了炎症,改善了肠道细菌,并恢复了肠道屏障功能,这表明它有可能预防性结肠炎.

科学领域:

药理学药理学是指药理学的学科.
胃肠病学胃肠病学
自然产品自然产品

背景情况:

性结肠炎 (UC) 是一种慢性炎症性肠病,治疗选择有限.
硫酸德克斯 (DSS) 诱导的小鼠结肠炎是研究UC病原和评估潜在治疗方法的标准模型.

研究的目的:

研究Anastatica hierochuntica精油 (EOAH) 对DSS诱导的实验性结肠炎的保护作用和潜在机制.
在大肠炎模型中评估EOAH对炎症标志物,肠道微生物群和肠道屏障完整性的影响.

主要方法:

用DSS诱导大肠炎的小鼠,然后用EOAH进行治疗.
评估的参数包括体重,疾病活动指数 (DAI),结肠长度,骨髓氧化酶 (MPO) 活性和促炎细胞因子水平 (TNF-α,IL-1β,IL-12).
机理学研究涉及分析NF-κB,PPARγ和NLRP3通路,肠道微生物群组成和紧结蛋白 (occludin,ZO-1) 的表达.

主要成果:

EOAH显著降低了DSS诱导的体重减轻,DAI,结肠缩短,组织损伤和MPO活动.
EOAH抑制了促炎性细胞因子 (TNF-α,IL-1β,IL-12) 并调节了NF-κB,PPARγ和NLRP3通路.
用EOAH治疗促进了有益细菌 (乳杆菌,双菌),减少了大肠杆菌,并恢复了结肠组织中的奥克卢丁和ZO-1表达.

结论:

在实验性结肠炎中,EOAH表现出显著的抗炎和保护作用.
这些机制包括调节关键的炎症途径和恢复肠道屏障功能.
阿纳斯塔蒂卡hierochuntica精油为性结肠炎的预防和治疗提供了一个有前途的自然治疗候选者.

关键词:

亚纳斯塔蒂卡是指一个高层的阴影.精油精油精油精油炎症剂是一种炎症剂.性结肠炎是一种

更多相关视频

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Published on: January 19, 2010

相关概念视频

Drugs for Treatment of Diarrhea-Predominant IBS

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...

Drugs for Treatment of Ulcerative Colitis in IBD

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...