3D生物打印瘤模型:通过回顾瘤微环境来克服免疫疗法耐药性的快速和方便的平台
Zhanyi Zhang1, Xuebo Chen2, Sujie Gao3
1Bethune Third Clinical Medical College, Jilin University, Changchun, 130021, China.
Cellular oncology (Dordrecht, Netherlands)
|March 23, 2024
概括
三维 (3D) 生物打印通过创建现实的瘤模型来推进癌症免疫疗法. 这些模型通过研究瘤微环境相互作用来帮助克服耐药性,以实现个性化医疗.
科学领域:
- 生物医学工程 生物医学工程
- 癌症研究 癌症研究
- 免疫治疗是一种免疫疗法.
背景情况:
- 癌症免疫疗法显示出有希望的结果,但由于复杂的瘤微环境 (TME) 而面临阻力.
- TME的细胞和非细胞组成部分对治疗耐药性有显著的贡献.
- 3D生物打印提供了一种模仿TME生理特征的方法,包括异质性和细胞矩阵相互作用.
研究的目的:
- 审查TME在免疫疗法耐药性中的作用.
- 突出3D生物打印作为研究TME介导耐药性的工具.
- 探索3D生物打印模型对个性化癌症免疫治疗的潜力.
主要方法:
- 总结有关TME成分和免疫疗法耐药性的现有文献.
- 介绍3D生物打印瘤模型的最新进展.
- 讨论了多细胞3D生物打印模型的构建.
主要成果:
- 3D生物打印模型准确地回顾了TME复杂性,包括细胞和非细胞交叉声.
- 这些模型在体内保留了瘤特征,如侵略性和异质性.
- 多细胞模型模拟了瘤细胞,免疫细胞,纤维细胞,脂肪细胞和细胞外基质之间的相互作用.
结论:
- 3D生物打印提供了一个研究和克服癌症免疫疗法耐药性的平台.
- 来自患者的3D生物打印模型可以为个性化治疗提供及时的信息.
- 将3D生物打印与其他技术 (如瘤) 结合起来,可以增强体外TME模拟.
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