相关实验视频
Updated: Jun 30, 2025
06:47
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
851
血小板和大血小板比率对于预测COVID-19的严重程度很有用
Hisae Sugihara1, Atsushi Marumo2,3, Haruka Okabe4
1Division of Clinical Laboratory, Fussa Hospital, Fussa, Tokyo, Japan.
International journal of hematology
|March 23, 2024
概括
富萨血小板评分,使用血小板计数和血小板-大细胞比率 (P-LCR),有效预测COVID-19的严重程度. 2或更高的分数表明需要大量氧气支持的可能性更高.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 血小板在冠状病毒疾病 (COVID-19) 发病过程中发挥着复杂的作用.
- 预测COVID-19的严重程度对于及时的医疗干预和资源分配至关重要.
研究的目的:
- 评估血小板指数在预测COVID-19严重性的有用性.
- 开发一种用于COVID-19严重程度评估的新型评分系统.
主要方法:
- 在COVID-19患者的血小板指数与不同氧气需求和非COVID-19对照的血小板指数进行比较.
- 利用了血小板指数的多变量分析和时间过程分析.
- 开发了基于血小板计数和血小板大细胞比率 (P-LCR) 的Fussa血小板评分.
主要成果:
- 低血小板计数 (≤16.6 × 104/μL) 和高的P-LCR (≥27.8%) 是COVID-19严重程度的显著预测因素.
- 富萨血小板评分 (≥2) 与增加的氧气需求密切相关 (无事件生存率P < 0.00000001).
- 血小板指数在发病6-10天后显著增加.
结论:
- 富萨血小板评分是预测COVID-19严重程度的快速,廉价和有效工具.
- 这一分数可能有助于识别需要转移到重症监护机构的患者.
相关概念视频
01:18Structure and Function of Platelets
1.1K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.1K
01:22Formation of the Platelet Plug
6.1K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
6.1K