肥胖和脂肪的分布与腹腔的风险之间的因果关系
Hekai Shi1, Qian Wu1, Nuojin Guo2
1Department of General Surgery, Fudan University Affiliated Huadong Hospital, Shanghai, China.
World journal of surgery
|March 23, 2024
概括
肥胖增加了腹腔 (VH) 的风险. 增加的身体脂肪百分比和内脏脂肪,以及更大的腰围和部周长,与更高的VH风险有因果关系,而不是皮下脂肪.
科学领域:
- 手术流行病学手术流行病学
- 遗传流行病学遗传流行病学
- 肥胖研究的研究.
背景情况:
- 腹腔 (VH) 是一个普遍的手术条件.
- 肥胖是已知的VH风险因素,但脂肪分布的具体作用尚不清楚.
研究的目的:
- 为了调查各种肥胖指标和VH风险之间的因果关系.
- 为了澄清脂肪分布对腹腔的发展的影响.
主要方法:
- 利用孟德尔的随机化 (MR) 分析与来自欧洲祖先的大规模全基因组关联研究数据.
- 评估的一般肥胖 (BMI,体脂百分比,体脂量) 和腹部脂肪 (内脏/皮下脂肪体积,腰/部周长,腰部比率).
- 使用双样本MR和多变量MR推断因果关系并调整混因子.
主要成果:
- 较高的BMI,体脂百分比,体脂质量,内脏脂肪组织,腰围和部周长显示与增加的VH风险存在因果关系.
- 皮下脂肪组织和腰部与部的比率与VH风险没有显著关联.
- 多变量MR证实体脂肪百分比是VH风险的因果因素,独立于BMI,糖尿病和吸烟.
结论:
- 一般的肥胖,特别是增加的内脏脂肪,更大的腰和部周长,与更高的腹腔漏风险有因果关系.
- 皮下脂肪和腰比似乎不是直接的因果因素.
- 这些发现增强了对脂肪分布在VH病原发生中的作用的理解.
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