长期COVID的微生物学概况以及相关的临床和放射学发现:一个前性的横截面研究
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Monalisa Dey1, Baijayantimala Mishra1, Prasanta Raghab Mohapatra2
1Departments of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, India.
Laboratory medicine
|March 23, 2024
概括
微生物感染在长期COVID患者的24%中存在,特别是那些住院或患有喘的人. 病毒感染与咳和肌痛相关,而细菌感染与生产性咳相关.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 病毒学 病毒学
- 细菌学 细菌学是一门学科.
背景情况:
- 长期COVID是一种SARS-CoV-2感染后的持续性疾病,可以表现为各种呼吸道症状.
- 在长期COVID患者中,这些呼吸道症状的微生物病因仍然不完全理解.
- 鉴定病原体对于了解疾病机制和指导治疗至关重要.
研究的目的:
- 确定长期COVID患者呼吸道感染的微生物原因的频率.
- 调查这些感染与临床/放射学发现之间的关联.
- 探索与并发症和疾病严重程度的关系.
主要方法:
- 收集了97名长期COVID患者的鼻和唾液,这些患者患有呼吸系统疾病.
- 微生物学分析用于识别细菌和病毒病原体.
- 微生物学发现与临床症状和放射学证据的相关性.
主要成果:
- 23%的长期COVID患者 (n=23) 显示有病毒,细菌或共感染的证据.
- 微生物在住院患者,中度COVID-19患者和喘患者中更频繁 (P < .05).
- 病毒感染与咳和肌痛有关;细菌感染与生产性咳有关. 61%的人患有COVID后纤维化变化.
结论:
- 在长期COVID中观察到呼吸道病原体 (病毒和细菌) 的下降趋势.
- 需要对更大的队列进行进一步的研究,以建立有关症状与并发症和严重性相关的高水平证据.
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