解读JAK/STAT信号通路:对瘤发生,进展和治疗干预的多方面的方法
Yihui Wang1, Zhe Wang2, Shuyu Li2
1Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan Province 450001, PR China; Department of Anesthesiology, School of Clinical Medicine, Zhengzhou University, Zhengzhou, Henan Province 450001, PR China.
International immunopharmacology
|March 23, 2024
概括
针对Janus酶/信号转换器和转录激活器 (JAK/STAT) 途径提供了新的抗癌策略. 这篇评论详细介绍了未来癌症干预措施的代理,机制和药物耐药性等挑战.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 简氏激酶/信号转换器和转录激活器 (JAK/STAT) 途径对于细胞信号传输至关重要.
- JAK/STAT通路的调节失调越来越多地与恶性瘤进展有关.
- 缺乏针对JAK/STAT通路的抗癌药物的系统摘要.
研究的目的:
- 提供针对JAK/STAT癌症治疗途径的药物剂的全面审查.
- 阐明这些药物的抗癌机制,包括抗增殖性,前性,抗转移性和抗血管性作用.
- 讨论临床挑战,如药物耐药性,并探索新的治疗策略.
主要方法:
- 对针对JAK/STAT途径的药物剂的文献综述.
- 对这些药物使用的各种抗癌机制的分析.
- 探索耐药性挑战和组合治疗方法.
- 基于纳米载体的药物输送策略的研究.
主要成果:
- 确定了植物化学物质,合成药物和生物分子作为向JAK/STAT通路的代理物.
- 详细的机制包括抑制增殖,诱导亡,抑制转移和血管生成.
- 强调药物耐药性的临床挑战.
- 强调了组合疗法和纳米载体介导药物递送的潜力.
结论:
- JAK/STAT通路抑制剂通过多种机制显示出显著的抗癌作用.
- 通过组合疗法和先进的药物输送系统 (如纳米载体) 克服耐药性至关重要.
- 针对JAK/STAT路径代表了瘤干预的有希望和不断发展的前沿.
相关概念视频
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
The JAK-STAT Signaling Pathway
8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.9K
Notch Signaling Pathway
4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K
PI3K/mTOR/AKT Signaling Pathway
3.5K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.5K
Non-Canonical Wnt Signaling Pathways
7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
Amplifying Signals via Enzymatic Cascade
8.5K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
8.5K


