分析混合重金属暴露和早期损伤之间的关系,基于加权量子和回归和贝叶斯核机器回归模型
Qi An1, Qingyao Wang1, Rujie Liu2
1Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China; Key Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan 030001, China.
概括
混合重金属暴露,包括和,与早期损伤标志物,如尿N-乙-β-D-葡萄糖酶和尿白有关. 金属之间的复杂相互作用也可能影响损伤.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 职业和环境重金属暴露与功能受损有关.
- 混合重金属暴露对慢性损伤和金属间相互作用的影响需要进一步调查.
研究的目的:
- 评估一般人群中混合重金属暴露的情况.
- 调查混合重金属暴露和早期功能障碍指标之间的关系.
- 探索重金属之间与损伤有关的潜在相互作用.
主要方法:
- 在中国太原市的两个社区进行横截面研究.
- 使用多重线性回归,加权量子总和 (WQS) 回归和贝叶斯内核机器回归 (BKMR).
- 评估尿液N-乙-β-D-葡萄糖酶 (UNAG) 和尿液白蛋白 (UALB) 作为早期损伤的指标.
主要成果:
- WQS回归表明混合重金属暴露与UNAG/UALB之间存在显著的正相关性.
- (As) 和 (Cd) 是UNAG水平的主要贡献者; (Ni), (Mn),Cd和As影响了UALB.
- BKMR揭示了复杂的相互作用,包括涉及As的负相互作用和Mn和Ni与其他金属之间的积极相互作用.
结论:
- 混合重金属暴露 (Cd, Cr, Pb, Mn, As, Co, Ni) 与UNAG和UALB正相关.
- 不同重金属之间存在复杂的多方向相互作用,涉及损伤标志物.
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