在椎脊髓损伤中,研究了与上肢运动功能相关的皮质脊髓抑制
Tarun Arora1, Jia Liu2, Akhil Mohan2
1Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, OH, USA; Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital, Norway.
概括
在脊髓损伤 (SCI) 后,通过对侧静止期 (CSP) 测量皮质脊髓抑制,在较强和较弱的手臂肌肉之间存在差异. 这些CSP的差异与SCI患者的上肢功能恢复有关.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 发动机控制器的控制器
背景情况:
- 皮层脊髓抑制机制对于脊髓损伤 (SCI) 后的功能恢复至关重要,但其损伤后的特征尚不清楚.
- 反侧静止期 (CSP) 是使用跨磁刺激 (TMS) 测量皮质脊髓抑制的尺度,在SCI文献中发现的结果不一致.
- 在不同弱度的肌肉中调查CSP可能会澄清不一致性和皮质脊髓抑制在SCI后上肢功能中的作用.
研究的目的:
- 在患有慢性SCI的个体中使用CSP调查皮质脊柱抑制.
- 为了比较SCI后较强 (双) 与较弱 (三) 肌肉中的CSP特征.
- 确定SCI中CSP和上肢功能能力之间的关系.
主要方法:
- 研究了27名患有慢性C1-C8SCI的成年人和16名身体健康的参与者.
- 在双肩 (强度3-5) 和三脚 (强度1-3) 肌肉中评估CSP.
- 使用上肢测试能力 (CUE-T) 评估上肢功能.
主要成果:
- 与对照人群相比,患有SCI的个体表现出双肩中延长的CSP,但三肌中延迟和减少的CSP.
- 两肌中早期出现的CSP和三肌中更长,更深的CSP与更好的CUE-T得分相关.
- 这些发现表明,内化水平影响SCI中CSP特征.
结论:
- 在SCI中,皮质脊柱抑制在较强的双肩中更为明显,但在较弱的三脚肌中减弱.
- 与损伤相对的内化程度会影响CSP在SCI中的发现.
- 在脊髓损伤后,CSP仍然与评估和理解上肢功能有关.
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