通过体外胃肠道模拟可以在土壤中预测的生物利用性吗?
Yiming Sun1, Kevin Jones2, Zongquan Sun3
1State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
与其他体外方法相比,统一的BARGE方法的胃阶段 (UBMG) 最好预测污染土壤中的 (As) 生物可用性. 这一发现改善了对暴露的人类健康风险评估.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 地质化学 地质化学
背景情况:
- (As) 是一种有毒的土壤污染物,对人类健康构成风险.
- 准确预测As的生物可用性对于风险评估至关重要.
- 现有的体外 (in vitro) 方法显示出适用于评估金属 (loid) 生物可用性的可变性.
研究的目的:
- 评估四种常见的体外胃肠道模拟方法的有效性,以预测土壤A的生物可用性.
- 将体外预测与使用工业污染土壤的体外动物模型进行比较.
主要方法:
- 测试了基于生理学的提取试验 (PBET),体外胃肠道方法 (IVG),可溶性生物利用性研究联盟 (SBRC) 和统一的BARGE方法 (UBM).
- 在10个工业污染土壤中被评估为相对生物利用率 (RBA).
- 与体内动物模型相比,经过验证的体外结果.
主要成果:
- 在测试的土壤中,土壤As RBA的差异很大 (15%68%).
- 不同的胃肠道模拟方法产生了不同的生物可访问性结果.
- 统一BARGE方法 (UBMG) 的胃阶段与体内AsRBA (R2 = 0.81) 的相关性最强.
结论:
- 与PBET,IVG和SBRC相比,UBMG在预测土壤A的生物利用性方面表现优越.
- 这项研究为改进受污染地点的人类健康风险评估提供了证据.
- 这些发现支持使用UBMG来在环境风险评估中更准确地预测生物可用性.
相关概念视频
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