在抑制肝细胞癌生长和转移的Codonopsis pilosula的分子机制
1Chongqing Three Gorges Medical College, Chongqing 404120, China; Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area, Chongqing 404120, China.
概括
科多诺opsis pilosula通过向CDK1和PDK1/β-catenin通路来抑制肝癌,减少瘤生长,转移和茎状. 这种传统中医药为肝细胞癌提供了潜在的治疗策略.
科学领域:
- 综合性瘤学是一种综合性瘤学.
- 传统中医药 (TCM) 药理学 药理学
- 癌症的分子机制 癌症的分子机制
背景情况:
- 肝癌是全球普遍存在的恶性瘤,需要新的治疗策略.
- 传统中国医学,包括Codonopsis pilosula,在癌症治疗方面显示出有前途.
- 科多诺普西斯·皮鲁拉 (Codonopsis pilosula) 具有与癌症治疗相关的抗炎和抗氧化特性.
研究的目的:
- 阐明Codonopsis pilosula在抑制肝细胞癌 (HCC) 的分子机制.
- 研究Codonopsis pilosula在调节CDK1和HCC中PDK1/β-catenin信号轴中的作用.
主要方法:
- 网络药理学,转录组测序和生物信息学分析确定了35个向基因.
- 在体外研究 (Huh-7细胞) 评估了细胞活力,增殖,细胞亡,迁移,EMT和干性.
- 在肝癌动物模型中的体内研究评估了瘤生长,亡和信号通路调节.
主要成果:
- 在Codonopsis pilosula多糖溶液 (CPP) 中,CDK1被确定为一个关键目标.
- 通过向CDK1/PDK1/β-catenin,CPP抑制了HCC细胞中的增殖,迁移,EMT和干细胞.
- 在体内研究证实了CPP通过这种信号轴抑制瘤生长和诱导亡的能力.
结论:
- 科多诺普西斯囊菌有效抑制肝细胞癌的进展.
- 该机制涉及CDK1的抑制和PDK1/β-catenin通路的调节.
- 这些发现支持Codonopsis pilosula作为肝癌的潜在治疗剂.
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