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在长效注射剂中解锁新的维度,使用基于脂质美索的珠子

Elena Allegritti¹, Luisa Giansanti¹, Gregor Bordon²

¹Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila, 67100 Coppito, L'Aquila, Italy.

Journal of colloid and interface science

|March 23, 2024

概括

脂质介质酶珠提供了一个稳定,生物相容的平台,用于持续的药物输送. 维生素E的结合允许可调节的释放,使得有针对性的注射配方能够减少全身暴露.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
纳米技术纳米技术

背景情况:

脂质中相 (LMP) 是生物相容和生物降解的材料.
基于LMP的珠子的高表面比体积比可以增强材料的性能.
控制药物释放对于有效和安全的治疗方法至关重要.

研究的目的:

为了研究基于LMP的珠子用于持续的药物输送.
用维生素E来调节药物释放动力学.
开发一种可注射配方,用于向药物管理.

主要方法:

基于LMP的珠子的制造.
加入抗氧化剂维生素E来影响中相拓.
装载了四种不同的药物,具有很高的捕获效率 (>80%).
药物释放特征的评估和可注射配方的开发.

主要成果:

基于LMP的珠子表现出增强的强度,稳定性和表面相互作用.
维生素E成功调节了中相拓和药物扩散.
对于所有测试药物来说,无论化学特性如何,都实现了持续的药物释放.
成功开发了一种可注射配方,使得有针对性的输送成为可能.

结论:

基于LMP的珠子是持续和有针对性的药物输送的有希望的材料.
开发的注射配方可最大限度地减少全身暴露和不良影响.
这种方法为各种治疗应用提供了一个多功能平台.

关键词:

珠子珠子珠子药物交付是药物交付的过程.在中相阶段 (Mesophases) 中.持续释放的个人资料持续释放的个人资料

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