尘埃颗粒物增加肺栓塞发病率:在中国进行的一项全国时间分层的病例交叉研究
Can Zhang1, Dan Zhao2, Feng Liu3
1China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
短期暴露于尘埃颗粒物 (PM),特别是细尘PM2.5,显著增加了肺栓塞 (PE) 发病的风险. 减少尘埃颗粒物排放对于公共卫生至关重要.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 流行病学 流行病学
背景情况:
- 对颗粒物 (PM) 的暴露与肺栓塞 (PE) 的风险增加有关.
- 尘埃PM是PM的重要组成部分,由于气候变化而升级.
- 关于尘埃PM对PE发作的特定影响的数据有限.
研究的目的:
- 调查不同尺寸粉尘PM (PM10,PM2.5-10,PM2.5) 分数与PE发病之间的关联.
- 分析尘埃PM暴露对PE发展的时间滞后效应.
- 根据人口和季节性因素来探索风险的潜在变化.
主要方法:
- 在中国 (2015-2020年) 进行了一项全国性病例交叉研究,涉及18616例PE病例.
- 使用条件后勤回归来评估尘埃PM度与PE发作之间的关系.
- 使用时间分布的滞后模型和按性别,年龄,地区和季节进行分层分析.
主要成果:
- 所有尘埃PM大小分数 (PM10,PM2.5-10,PM2.5) 都与增加PE发病风险显著相关,特别是在暴露的同一天.
- 尘埃PM2.5增加10μg/m3显示PE发病的几率比率 (1.039) 是最高的.
- 在温暖的季节观察到更高的PE风险,特别是对尘埃PM2.5暴露.
结论:
- 短期暴露于尘埃PM,特别是PM2.5,是PE发病的重要触发因素.
- 公共卫生战略应专注于减轻尘埃PM排放.
- 保护个人,特别是那些面临PE风险的人,免受尘埃PM暴露至关重要.
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