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Updated: Jun 30, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Published on: June 27, 2020

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转录延长缺陷将瘤性SF3B1突变与染色体格局的可针对性改变联系起来

Prajwal C Boddu1, Abhishek K Gupta1, Rahul Roy1

  • 1Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, 300 George Street, Suite 786, New Haven, CT 06511, USA.

Molecular cell
|March 23, 2024
PubMed
概括

与癌症相关的SF3B1突变通过破坏前结合体组合来损害RNA聚合酶II转录. 调节表观遗传因子可以逆转这些效应,建议针对Sin3/HDAC复合物的新治疗策略.

关键词:
对DNA损伤的反应反应在R-Loop中使用.的RNA聚合酶II.在SF3B1中.在Sin3/HDAC中使用.这就是U2AF1AF1.这是WDR5的WDR5.同转录的拼接.拼接一个osomeome.转录 转录 是一种转录.

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