聚 ((D,l-乳酸-co-glycolide) 颗粒由肠道微生物组代谢,并提升短链脂肪酸
Laura E McCoubrey1, Fabiana Ferraro2, Nidhi Seegobin1
1UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
概括
低分子量聚D,l-乳酸-co-glycolide (PLGA) 被肠道微生物代谢,增加有益的短链脂肪酸 (SCFA) 和减少有害的. 这表明PLGA是PLGA.
科学领域:
- 微生物学 微生物学
- 生物材料科学 生物材料科学
- 胃肠病学 胃肠病学
背景情况:
- 结肠微生物组产生短链脂肪酸 (SCFA),对肠道健康至关重要,包括屏障功能和抗致癌作用.
- 目前用于提高SCFA生产的方法是不理想的.
- 聚,D,l-乳-co-glycolide) (PLGA) 被探索为微生物SCFA合成的潜在基质.
研究的目的:
- 为了研究人类结肠中PLGA的微生物代谢.
- 评估PLGA在增强SCFA生产和调节肠道微生物群方面的潜力.
- 评估PLGA在炎症结肠模型中的炎症标记物的影响.
主要方法:
- 在M-SHIME®系统中对两个PLGA等级和乳酸控制进行查,这是一个先进的人类结肠模型.
- 对SCFA度,含量和微生物组成的分析.
- 在炎症结肠表皮模型中对PLGA对炎症标志物表达的影响进行了体外评估.
主要成果:
- 低分子量PLGA (PLGA2) 被结肠微生物群代谢,在48小时内释放乳酸.
- PLGA 2的使用导致了和丁酸盐度的增加.
- 治疗PLGA减少了有害的氨合成,并以一种特定于供体的方式调节了微生物群组成.
- 在炎症结肠模型中,PLGA影响了亲和抗炎标记物的表达.
结论:
- PLGA容易受到肠道微生物群的酶降解.
- PLGA代谢可以在治疗上提升有益的SCFA,并减少有害的化合物,如.
- PLGA证明了调节肠道微生物群和炎症反应的潜力,为肠道健康提供了一个新的治疗策略.
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