对于局部晚期的基底细胞癌,地平线上的治疗方法
Munir H Idriss1, Carolyn M Stull1, Michael R Migden2
1Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Cancer letters
|March 23, 2024
概括
基础细胞癌 (BCC) 是一种常见的癌症,可以局部发达 (laBCC) 并抵抗标准治疗. 新的疗法,如刺抑制剂和免疫疗法提供了选择,正在进行对laBCC.新型药物的研究.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
背景情况:
- 基底细胞癌 (BCC) 是一种常见的人类癌症,结果通常有利.
- 局部先进的BCC (laBCC) 提出了挑战,通常是无法切除或抗辐射的.
- 对laBCC的既定治疗方法包括刺抑制剂和PD-1抑制剂免疫疗法,尽管它们有局限性.
研究的目的:
- 审查当前针对局部晚期基底细胞癌的治疗方法.
- 讨论刺抑制剂和PD-1抑制剂在laBCC管理中的作用.
- 突出新兴疗法和正在进行的高级BCC临床试验.
主要方法:
- 对laBCC.的已知和正在研究的治疗方法的文献综述.
- 对治疗指南和临床试验数据的分析.
- 综合有关药物的疗效,副作用和患者结局的信息.
主要成果:
- 刺抑制剂 (vismodegib,sonidegib) 是laBCC的第一线药物.
- PD-1 抑制剂免疫疗法 (cemiplimab) 是对刺抑制剂的进展或不耐受的一种选择.
- 由于目前治疗方法的适度反应和副作用,正在研究新型治疗方法.
结论:
- 治疗laBCC需要仔细考虑患者的因素和瘤特征.
- 虽然目前的治疗方法有好处,但需要更有效和更耐受的治疗方法.
- 持续的研究对于推进局部先进的基底细胞癌的管理至关重要.
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