叶酸和血脂质:叶酸补充剂的相互作用和作用
Federica Fogacci1, Carmine Pizzi2, Luca Bergamaschi3
1Hypertension and Cardiovascular risk factors Research Unit, Medical and Surgical Sciences Dept., Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Current problems in cardiology
|March 23, 2024
概括
叶酸补充剂可以改善脂质水平,降低心血管疾病风险,特别是脑血管疾病. 这种低成本的干预措施表明,它有望在患有脱脂症的患者中进行二次预防.
科学领域:
- 心血管医学 心血管医学
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 脱脂症和高血糖血是已确定的心血管疾病 (CVD) 风险因素.
- 虽然脂质优化可以降低心血管疾病的风险,但在所有人群中降低同型半氨酸的好处需要澄清.
- 动脉样硬化的发展和进展与脂质样本和同型半氨酸水平有关.
研究的目的:
- 审查叶酸补充剂对低密度脂蛋白胆固醇 (LDL-C) 水平和氧化的影响.
- 评估叶酸对动脉样硬化相关并发症的影响.
- 评估叶酸在心血管疾病二次预防中的作用.
主要方法:
- 科学文献的叙事评论. 科学文献的叙事评论.
- 在2024年1月之前,对电子数据库 (PubMed,科学网,Cochrane,Scopus) 进行全面搜索.
- 包括流行病学数据,病理生理学观察和随机临床试验的元分析.
主要成果:
- 叶酸补充证明了血脂水平的适度但显著改善.
- 有证据表明,与动脉样硬化相关的脂质动脉原性降低和早期血管损伤.
- 叶酸摄入与大脑血管疾病风险显著降低有关.
结论:
- 叶酸补充剂可能会积极影响脂质配置文件,并减少动脉样硬化进展.
- 该干预措施在降低脑血管疾病风险方面显示出显著的益处.
- 鉴于其安全性和低成本,长期补充叶酸是一种可行的考虑因素,用于在失脂症患者中预防二次心血管疾病.
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