开发基于氨解聚乳酸的多孔薄膜,用于pH响应的持续药物递送装置
Ammara Rafique1, Y Emre Bulbul2, Zulfiqar Ali Raza3
1Department of Applied Sciences, National Textile University, Faisalabad 37610, Pakistan; Department of Chemistry, Suleyman Demirel University, Faculty of Engineering and Natural Sciences, 32220 Isparta, Turkey.
International journal of biological macromolecules
|March 23, 2024
概括
研究人员开发了适应pH的聚乳酸膜,用于药物输送. 这些修改后的多孔膜有效地吸收和释放阿米卡辛硫酸,显示生物医学应用的希望.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 聚乳酸 (PLA) 是一种广泛用于药物输送的生物材料.
- 原生PLA表面缺乏足够的功能组,以有效地进行药物加载和释放.
- 多孔和水友的表面提高了药物携带系统的性能.
研究的目的:
- 合成适应pH值,多孔的多乳酸薄膜.
- 通过氨解来定制PLA薄膜的物理化学和表面特性.
- 通过使用这些修饰的薄膜,研究阿米卡辛硫酸的吸收和释放.
主要方法:
- 聚乳酸) 薄膜的氨解,以引入氨基群.
- 宁水林试验以量化氨基群密度.
- 电子显微镜和FTIR光谱分析表面形态和特性.
- 浸透性测试用于评估水友性.
- 在不同的pH值 (5.5和7.4) 下进行药物加载和释放研究.
- 药物释放数据的动态建模.
主要成果:
- 氨解成功地将氨基群引入了PLA表面,同时保持了多孔形态.
- 经过修改的PLA薄膜表现出增强的水友性.
- 片表现出pH响应性行为,在pH 5.5时吸收阿米卡辛硫酸盐,在pH 7.4.时释放.
- 药物释放跟随第一阶级动力学,表明可预测的释放概况.
- 经过修改的薄膜显示出良好的热稳定性.
结论:
- 氨基化多孔PLA薄膜对于对pH响应的阿米卡辛硫酸盐的负载和释放是有效的.
- 这些修改过的片为先进的药物输送应用提供了一个有前途的平台.
- 这项研究开创了可膨胀,氨基化PLA薄膜的使用,用于pH响应的阿米卡辛硫酸盐输送.
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