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从COVID-19前到后的海马神经代谢和结构变化:一个案例系列研究

Wouter A J Vints¹, Kristina Valatkevičienė², Oron Levin³

¹Department of Health Promotion and Rehabilitation, Lithuanian Sports University, LT-44221 Kaunas, Lithuania; Department of Rehabilitation Medicine Research School CAPHRI, Maastricht University, P.O. Box 616, 6200 MD Maastricht, the Netherlands; Adelante Zorggroep, P.O. Box 88, 6430 AB, Hoensbroek, the Netherlands.

Magnetic resonance imaging

|March 23, 2024

概括

轻微的COVID-19感染可能会导致海马神经炎症和降低谷氨酸水平,可通过磁共振光谱检测. 这些发现可能解释COVID-19幸存者的长期神经症状.

科学领域:

神经学神经学
神经成像是一种神经成像.
传染性疾病传染性疾病

背景情况:

COVID-19 感染可能导致神经复杂症,可能是由无法检测的神经化学和结构性大脑异常引起的.
这项研究专注于经历了轻度COVID-19症状的老年人.

研究的目的:

在COVID-19感染之前和之后,检查海马体内主体内神经代谢和结构性大脑变化.
为了调查COVID-19与大脑化学和结构的变化之间的潜在联系.

主要方法:

利用整个大脑磁共振成像 (MRI) 和左海马的质子磁共振光谱 (1H-MRS).
收集了来自三名老年人 (年龄在63-68岁) 的COVID-19感染前和后的数据.
感染后的措施与感染前的基线和对照组的最小可检测变化 (MDC) 值进行了比较.

主要成果:

在COVID-19后的两名患者 (≥42.0%) 中观察到谷氨酸-谷氨胺 (Glx) 的显著减少.
在COVID-19 (≥36.4%) 后的一名患者中检测到肌肉内醇 (mIns) 和N-乙酸 (NAA) 的升高.
核磁共振扫描显示,两名患者的海马体积增加,一名患者的体积保持不变.

结论:

轻微的COVID-19感染可能与局部海马神经炎症和降低谷氨酸水平有关.
1H-MRS的发现为了解COVID-19长途旅行者的慢性神经和心理问题提供了潜在的临床价值.

关键词:

在 COVID-19 疫情中,运动运动运动.磁共振成像技术磁共振成像技术心理功能心理功能神经化学物质的神经化学物质

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