脉压与糖尿病前期风险之间的非线性关系:一项二次回顾性中国队列研究
Changchun Cao1, Yong Han2, Haofei Hu3
1Department of Rehabilitation, Shenzhen Dapeng New District Nan'ao People's Hospital, Shenzhen, Guangdong, China.
BMJ open
|March 23, 2024
概括
高脉压 (PP) 是中国成年人糖尿病前期 (DM前期) 发展的独立风险因素. 当PP超过29mmHg时,这种风险是显著的,表明非线性关系.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 流行病学 流行病学
背景情况:
- 脉压 (PP) 与2型糖尿病的发展有关.
- PP和糖尿病前期 (糖尿病前期) 之间的关系仍未得到充分研究.
研究的目的:
- 在一个大型的中国队列中调查PP和事件前DM之间的关联.
- 确定影响这种关系的潜在门和人口因素.
主要方法:
- 二次回顾性队列分析使用来自182,672名中国人的数据 (2010-2016).
- 考克斯比例危险回归被用来分析基线PP和事件前DM之间的关联.
- 糖尿病前期被定义为受损的禁食葡萄糖水平 (5.66.9 mmol/L).
主要成果:
- 在PP和事件前DM (HR 1.009) 之间发现了正相关性.
- 确定了一个非线性关系,当PP高于29毫米升时,观察到一个显著的关联.
- 亚组分析表明,女性,从不吸烟者和非肥胖个体的相关性更强.
结论:
- 升高的PP是中国人口中发展前-DM的独立风险因素.
- 29 mm Hg 的 PP 值区分了事件前DM的显著风险水平.
- 这些发现突显了监测PP对于预先DM风险分层的重要性.
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