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Updated: Jun 30, 2025

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在DNA复制过程中,FANCJ促进了PARP1活动,这在BRCA1缺陷细胞中至关重要

Ke Cong1, Nathan MacGilvary1, Silviana Lee1

  • 1Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.

Nature communications
|March 24, 2024
PubMed
概括

聚 (ADP-ribose) 聚合酶抑制剂 (PARPi) 的有效性取决于FANCJ DNA螺旋酶和S相PARP1活性. FANCJ的损失影响了PARPi的耐药性,特别是在BRCA1缺乏的细胞中,突出了PARP1.

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