Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Nucleoside-modified PVA hydrogel with antibacterial and wet-adhesion properties accelerates healing of diabetic oral ulcers.

Biomaterials science·2026
Same author

Injectable Matrix Metalloproteinase-Responsive Nanoparticle Hydrogel Scaffold for Sustained Local Drug Delivery in Fibrous Dysplasia.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Systemic immune-inflammation index and its role in the relationship between subgingival microbiota and periodontal inflammation.

Journal of periodontology·2026
Same author

Machine learning-driven discovery of therapeutic nucleoside hydrogels for periodontitis.

International journal of oral science·2026
Same author

Clinical and Radiographic Outcomes of Transcrestal Sinus Floor Elevation With RBH of 3-5 mm: A Retrospective Study.

Clinical implant dentistry and related research·2026
Same author

Research progress in heterogeneity of dental mesenchymal stem cells.

International journal of oral science·2026

相关实验视频

Updated: Jul 1, 2026

Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization
08:03

Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization

Published on: November 12, 2014

10.5K

开发一种基于描述符的机器学习模型,用于基于描述符的精确核酸基预测.

Weiqi Li1, Yinghui Wen1, Kaichao Wang1

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, PR China.

Nature communications
|March 24, 2024
PubMed
概括
此摘要是机器生成的。

科学家们开发了一种机器学习模型,以预测核酸衍生物中的水凝形成. 该工具有助于发现具有潜在生物医学和传感应用的新型水凝.

更多相关视频

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

7.9K
Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models
10:49

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

2.6K

相关实验视频

Last Updated: Jul 1, 2026

Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization
08:03

Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization

Published on: November 12, 2014

10.5K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

7.9K
Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models
10:49

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

2.6K

科学领域:

  • 生物材料科学 生物材料科学
  • 超分子化学 超分子化学
  • 计算化学计算化学

背景情况:

  • 由于生物相容性,核酸衍生的超分子水凝在生物医学中显示出希望.
  • 从核酸衍生物中预测水凝的形成仍然是一个重大挑战.
  • 缺乏预测模型阻碍了新凝材料的发现.

研究的目的:

  • 开发一种机器学习模型,用于预测核酸衍生物的凝形成能力.
  • 为了识别具有水凝能力的新型核酸衍生物.
  • 探索新发现的水凝的潜在应用.

主要方法:

  • 机器学习模型开发使用71个核酸衍生物的数据集.
  • 模型优化和验证以达到71%的准确性.
  • 对所选分子的水凝形成进行实验验证.

主要成果:

  • 建立了一个准确的机器学习模型 (准确率为71%),用于预测水凝的形成.
  • 通过计算选了24种核酸衍生物,并通过实验证实了它们的凝形成能力.
  • 发现并描述了两种新的离子独立的核酸.
  • 离子独立的水凝显示出检测Ag+和cysteine的潜力.

结论:

  • 机器学习为预测核酸衍生物水化提供了有价值的工具.
  • 发现的离子独立水凝为传感应用提供了新的可能性.
  • 这种方法加速了功能性超分子水凝的发现和开发.