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Updated: Jun 30, 2025

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
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胰岛素受体通过胰岛素样生长因子2的激活

Weidong An1, Catherine Hall2, Jie Li1

  • 1Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Nature communications
|March 24, 2024
PubMed
概括

与胰岛素相比,胰岛素样生长因子2 (IGF2) 通过不同的机制激活胰岛素受体 (IR). 低温-EM结构揭示了IGF2与IR异型 (IR-A和IR-B) 的结合如何导致不对称激活,影响生长和新陈代谢.

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