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Updated: Jun 30, 2025

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一个第一阶段的,开放标签,质量平衡研究[14C]-伊伯多米德在健康受试者

Yiming Cheng1, Xiaomin Wang1, Liangang Liu2

  • 1Clinical Pharmacology, Pharmacometrics, Disposition and Bioanalysis, Bristol Myers Squibb, Princeton, NJ, USA.

European journal of drug metabolism and pharmacokinetics
|March 24, 2024
PubMed
概括

伊伯多米德是一种新型的大脑调节剂,在人类中经历生物转化,主要通过尿液和便作为不变药物和代谢物分泌. 这项研究描述了其代谢途径和分泌特征.

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
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