相关实验视频

Updated: Jun 30, 2025

An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis

An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis

Published on: August 6, 2020

长非编码RNAs在眼球血管生成和血管眼球病变中的作用

Pranali Gandhi¹, Yuzhi Wang², Guigang Li³

¹Tulane University School of Medicine, New Orleans, LA, 70112, USA.

Cell & bioscience

|March 24, 2024

概括

长非编码RNAs (lncRNAs) 调节基因表达,并与眼睛疾病有关. 本综述详细介绍了参与眼球血管生成的lncRNAs,并提供了对血管眼球病的潜在治疗点的见解.

科学领域:

分子生物学分子生物学
眼科医生眼科眼科
遗传学遗传学是一个

背景情况:

长非编码RNAs (lncRNAs) 是生理和病理过程中基因表达的关键调节者.
失调的血管生成是各种血管眼病的基础,如糖尿病视网膜病变和与年龄有关的黄斑变性.
目前针对这些疾病的抗VEGF疗法存在局限性,需要研究新的治疗策略.

研究的目的:

对眼睛血管生成中 lncRNAs 的当前理解进行审查.
在血管眼病症中探索特定的亲血管原和抗血管原 lncRNA 的功能和机制.
突出 lncRNAs 作为治疗眼睛疾病的治疗点的潜力.

主要方法:

关于眼睛血管生成中的lncRNAs最近研究的文献综述.
在血管眼病症模型中分析了研究 lncRNA 功能的研究.
关于特定 lncRNAs 的发现的总结,包括 ANRIL,HOTAIR,H19,MALAT1,MEG3 等.

主要成果:

包括ANRIL,HOTAIR,HOTTIP,H19,IPW,MALAT1,MIAT,NEAT1和TUG1在内的几种lncRNA被确定为亲血管性.
鉴定到的 lncRNAs MEG3 和 PKNY 是抗血管性.
人类/灵长类动物特定的lncRNAs如IncEGFL7OS也在眼睛血管生成的背景下进行讨论.

结论:

lncRNAs在调节眼球血管生成方面发挥着重要作用.
了解lncRNAs的特定功能可以为治疗血管眼病提供新的途径.
对lncRNA机制的进一步研究可能会导致对目前治疗无反应的患者改善治疗策略.

关键词:

血管新生的产生.眼睛疾病眼睛疾病长非编码RNA (lncRNA) 是一种长非编码RNA.眼球眼球眼球眼球眼球

更多相关视频

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Published on: December 9, 2022

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...