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探索ferulic acid/hydroxypropyl-β-cyclodextrin包含复合物的形成机制:光谱分析和计算机模拟

Junli Lv¹, Mengmeng Tan¹, Jiali Zou¹

¹School of Life Science & Technology, Inner Mongolia University of Science & Technology, Baotou, China.

Journal of the science of food and agriculture

|March 24, 2024

概括

酸 (FA) 复合与基-β-环氧化 (HP-β-CD) 增强了FA的稳定性和生物可用性. 这种包含复合体的形成改善了不溶性化合物的FA输送.

科学领域:

材料科学材料科学材料科学
制药科学制药科学
超分子化学超分子化学

背景情况:

酸 (FA) 具有宝贵的生物功能,但具有不良的溶解性和稳定性,限制了其生物利用性.
xypropyl-β-cyclodextrin (HP-β-CD) 是一个有前途的宿主分子,由于其独特的结构,可以封装疏水化合物.
用HP-β-CD复合FA提供了一个潜在的策略来克服FA的局限性.

研究的目的:

为了研究ferulic acid (FA) 和hydroxypropyl-β-cyclodextrin (HP-β-CD) 纳入复合物形成的机制.
为了确认FA/HP-β-CD纳入复合物的形成和特征.
评估复杂化对FA稳定性和生物可用性的影响.

主要方法:

福里埃变换红外光谱法 (FTIR) 和X射线衍射 (XRD) 被用来确认复杂的形成.
热重力测量衍生热重力测量 (TG-DTG) 评估了该综合体的热稳定性.
分子动力学模拟提供了对相互作用机制和结构变化的洞察.

主要成果:

FTIR和XRD证实了FA/HP-β-CD纳入复合物的形成.
TG-DTG分析显示,封装后FA的热稳定性得到了增强.
分子动力学模拟显示,受范德瓦尔斯力驱动的HP-β-CD内成功封装了FA,从而导致更紧的HP-β-CD结构和更好的FA生物可用性.

结论:

这项研究阐明了FA和HP-β-CD之间的相互作用机制.
形成FA/HP-β-CD纳入复合体有效地提高了FA的生物可用性.
这种方法有望为不溶性活性药物成分开发先进的输送系统.

关键词:

铁酸是什么意思铁酸是什么意思形成机制机制的形成机制基 propyl-β-cyclodextrin 的使用情况包容性复杂的包容性复杂的分子动力学模拟模拟

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