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Updated: Jun 30, 2025

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
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瓜尼丁-皮佩里丁切换可提供高亲和度小分子NPFF连接体,优先选择NPFF1-R和NPFF2-R亚型

Kareem A Galal1, Samuel Obeng2, Victoria L C Pallares1

  • 1Department of Medicinal Chemistry, College of Pharmacy, The University of Florida, Gainesville, FL, 32610, USA.

European journal of medicinal chemistry
|March 24, 2024
PubMed
概括

研究人员开发了新的无瓜尼丁Neuropeptide FF (NPFF) 受体连接体,8b和16a. 这些化合物提供了改善的药理动力学特性和亚型选择性,推进了NPFF受体系统研究.

关键词:
反阿片类药物系统.神经贝FF受体FF受体的神经贝FF受体非瓜因丁连接体的其他连接体.结构与活动的关系.亚型选择性的选择性

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