果果真菌素通过调节肠道微生物群,GLP-1分泌和免疫反应来保护小鼠免受烧伤
Ji-Wei Hao1, Hong-Sheng Liu2, Ling-Ying Liu3
1Trauma Repair and Tissue Regeneration Center, Department of Medical Innovation Study, Chinese People's Liberation Army General Hospital, Beijing 100853, People's Republic of China.
International immunopharmacology
|March 24, 2024
概括
含有水溶性rhamnogalacturonan-I丰富的果果真菌素 (WRP) 改善了肠道微生物群,并减少了受烧伤小鼠的死亡率. 酸性WRP (WRP-A) 更有效,抑制GLP-1并增强免疫反应.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 在水中溶解的Rhamnogalacturonan-I丰富果果真菌素 (WRP) 具有抗菌性质.
- 烧伤伤害导致肠道微生物失调和免疫失调.
研究的目的:
- 调查修改酸性 (A) 或中性 (B) WRP溶液在改善烧伤小鼠肠道微生物失生症方面的疗效.
- 为了确定WRP对死亡率,肠道微生物群,GLP-1水平,免疫反应和烧后肠道屏障功能的影响.
主要方法:
- 在受热伤害之前,雄性Balb/c小鼠被用WRPs (80,160,320 mg/kg) 进行了测试.
- 评估死亡率,体重,便DNA,T细胞代谢学,GLP-1,防御蛋白,免疫球蛋白和肠道屏障功能在特定时间点.
主要成果:
- 低剂量WRP-A显著降低了因烧伤引起的死亡率.
- 这两种WRP都通过减少促进炎症的细菌来减轻肠道微生物群的失生症.
- 两种WRPs都抑制了阴膜和血中的葡萄糖类1 (GLP-1) 水平.
- WRP-A改善了适应性免疫反应,而WRP-B降低了血防御蛋白和肠道透性.
结论:
- 酸性WRP (WRP-A) 通过调节肠道微生物群,抑制GLP-1分泌和增强适应性免疫力来降低燃烧引起的死亡率.
- 酸性和中性WRPs在治疗烧伤后的肠道失调症方面都有好处.
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