普罗波对有效的大脑网络的影响
D van Blooijs1, S Blok2, G J M Huiskamp2
1UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, PO Box 85500, 3584 GA Utrecht, The Netherlands; Stichting Epilepsie Instellingen Nederland (SEIN), P.O.box 540, 2130 AM Hoofddorp, The Netherlands.
概括
普罗波麻醉降低了通过单脉冲电刺激 (SPES) 在电皮质谱 (ECoG) 过程中检测到的有效大脑连接的数量. 然而,在propofol下,整体的大脑网络拓在很大程度上仍然保留着.
科学领域:
- 神经科学是一个神经科学.
- 麻醉学 麻醉学
- 的研究研究.
背景情况:
- 内电皮图 (ECoG) 对于手术规划至关重要.
- 了解麻醉对大脑网络的影响对于解释ECoG数据至关重要.
研究的目的:
- 调查普罗波麻醉对来自ECoG的有效大脑网络的影响.
- 为了比较清醒和麻醉状态之间的网络测量和皮质皮质唤起潜力 (CCEPs).
主要方法:
- 研究了9名接受ECoG治疗的患者.
- 单脉冲电刺激 (SPES) 在清醒状态 (SPES-临床) 和propofol-麻醉状态 (SPES-propofol) 中进行.
- 构建了有效的网络,并比较了网络指标 (不等级,异等级,中间中心性),N1峰值延迟和CCEP的幅度.
主要成果:
- 在普罗波麻醉下观察到较少的CCEPs.
- 在两种状态之间的内度,外度和中间中心度之间发现了显著的相关性.
- 在普罗波麻醉下,CCEP的N1峰延迟增加.
结论:
- 普罗波麻醉降低了有效网络连接的数量,但对网络措施的影响很小.
- 有效的大脑网络的主要拓在propofol麻醉下被保存.
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