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Updated: Jun 30, 2025

Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
最近的进展表明,nobiletin在治疗呼吸系统疾病方面的治疗潜力很大
Yanqin Qin1, Jingfan Yang2, Haibo Li2
1Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P.R. China, Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan Province, China.
类黄类固体诺比林因其抗炎和抗瘤特性,在治疗肺癌和COPD等呼吸道疾病方面表现有前途. 需要进一步的研究来探索它的全部治疗潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 诺比是果果皮中发现的一种聚甲化类黄.
- 它表现出抗瘤,抗炎,抗氧化和抗亡作用.
- 新出现的证据凸显了其在治疗各种呼吸道疾病 (RDs) 中的潜力.
研究的目的:
- 对一系列RDs进行对比,审查nobiletin的治疗潜力.
- 研究了nobiletin在肺癌,COPD,肺纤维化,喘,肺感染,急性肺损伤,COVID-19和肺动脉高血压中的疗效.
主要方法:
- 在PubMed,Web of Science和Scopus数据库中进行了全面的文献搜索.
- 关键词包括"nobiletin"与与肺部和呼吸系统疾病,代谢物,药理动力学和毒性相关的术语相结合.
- 在选298篇获取文章后,选择了53篇相关研究.
主要成果:
- 诺比素通过调节Akt/GSK3β/β-catenin,Bcl-2,PD-L1和PARP等途径来抑制癌细胞的增殖和迁移.
- 它针对治疗COPD和急性肺损伤 (ALI) 的炎症信号通路.
- 诺比利丁通过调节mTOR通路来证明在肺纤维化治疗中的有效性.
结论:
- 诺比利具有广泛的药理活性,高效率和低毒性,将其定位为预防和治疗RDS的潜在药物.
- 这些发现支持进一步调查nobiletin的分子机制.
- 需要进一步的临床前和临床研究来确定nobiletin在管理RDS中的作用.
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