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由于嗅觉输入的中断,嗅球和面向迁移流的组织学变化

Yukari Nakamura¹, Takaki Miwa¹, Hideaki Shiga¹

¹Department of Otorhinolaryngology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Japan.

Auris, nasus, larynx

|March 24, 2024

概括

在小鼠的嗅觉神经损伤抑制了神经细胞迁移和成熟在罗斯特拉移徙流 (RMS). 嗅觉上皮的恢复并没有恢复神经细胞分裂或嗅觉球泡结构.

科学领域:

神经科学是一个神经科学.
嗅觉系统生物学嗅觉系统生物学
细胞再生细胞再生

背景情况:

嗅球中的环球球体和颗粒细胞对于嗅觉信号传输至关重要.
这些细胞起源于腹腔下区域,并通过Rostral迁移流 (RMS) 迁移.
了解嗅觉神经元损伤恢复期间的神经细胞发育是有限的.

研究的目的:

为了研究嗅觉神经元退化和再生后嗅觉球和RMS的变化.
探索嗅觉神经损伤对神经细胞迁移和分化的影响.

主要方法:

在使用甲基马的成年小鼠中诱导了嗅觉神经退行.
组织学和免疫组织化学分析 (OMP,EDU,Doublecortin) 在各种时间点对鼻组织和大脑样本进行.
测量包括嗅觉上皮的恢复,OMP阳性纤维密度,质体积和RMS中的神经细胞计数/分裂.

主要成果:

甲马的使用导致了嗅觉上皮的退化,28天后部分恢复.
嗅觉淋巴细胞显示出显著的OMP纤维损失和体积减少,没有明显的恢复.
在RMS中神经细胞增殖在受伤后下降,并显示不完全的恢复,与对照组相比,分裂细胞较少.

结论:

嗅觉神经退化或嗅觉输入受损会抑制神经细胞分裂和RMS内的成熟.
即使在嗅觉上皮再生后,嗅觉质体的结构完整性也无法恢复.
这些发现突显了嗅神经损伤对神经发生和嗅球结构的持续影响.

关键词:

神经细胞质细胞质细胞.神经新生是神经发生的过程.嗅觉灯泡是一种嗅觉灯泡.嗅觉障碍是一种嗅觉障碍.嗅觉上皮质是一种嗅觉上皮质.罗斯特拉尔的迁徙流

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