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透析开始时的血清肌态素可能预测1年的死亡率和住院治疗
Midori Sakashita1, Yoshifumi Hamasaki2, Rikako Oki2
1Department of Hemodialysis and Apheresis, The University of Tokyo Hospital, Tokyo, Japan, msakashita-tky@umin.ac.jp.
Nephron
|March 24, 2024
概括
在透析开始时血清肌静素水平预测了患者的结果. 较低的肌静素度与新透析患者的死亡率和住院风险增加有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 生物化学 生物化学
- 临床医学 临床医学
背景情况:
- 骨肌肉的负调节剂myostatin与血液透析患者的死亡率有关.
- 透析启动时血清肌态素的预后价值仍然不清楚.
研究的目的:
- 调查透析开始时血清肌态素度与发生透析患者1年死亡率或住院治疗之间的关联.
主要方法:
- 在104名发生血液透析或腹腔透析患者 (2016-2018) 中,在透析开始时测量了血清肌性质激素水平.
- 用Kaplan-Meier和Cox比例危险模型分析了1年内死亡率和住院治疗的综合结果.
- 通过接受器运行特征分析来评估预测性性能.
主要成果:
- 血清肌态素水平较低的患者的1年生存率和无住院率明显较低 (p=0.0020).
- 肌静素水平与不良结果相反相关,独立于年龄 (HR 0.16;95% CI:0.05-0.57).
- 与营养和虚弱的临床指数相比,血清肌肉平衡素对1年不良结果具有优越的预测能力.
结论:
- 在透析开始时血清肌静止素度是发生透析患者不良结果的显著逆预测因素.
- 在开始透析的患者中,肌静止素可能作为一种有价值的风险分层生物标志物.
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