超加工食品的消费和刺激性肠综合征的长期风险:一个大规模的前性队列研究
Shanshan Wu1, Zhirong Yang2, Si Liu1
1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China; State Key Laboratory for Digestive Health, Beijing, China; National Clinical Research Center for Digestive Diseases, Beijing, China.
概括
更高的超加工食品 (UPF) 摄入量与患上刺激性肠综合征 (IBS) 的风险增加有关. 这项大规模的英国研究发现了UPF消费和发生IBS病例之间的剂量反应关系.
科学领域:
- 胃肠病学 胃肠病学
- 营养流行病学 营养流行病学
- 公共卫生 公共卫生
背景情况:
- 刺激性肠综合征 (IBS) 是一个严重的疾病负担.
- 超加工食品 (UPF) 的消费量与IBS患病率同步上升.
- 有限的流行病学数据存在于UPF消费和IBS风险之间的关联.
研究的目的:
- 调查与超加工食品 (UPF) 消费相关的刺激性肠综合征 (IBS) 的长期风险.
- 分析UPF摄入量和IBS发展之间的剂量-反应关系,在一个大型前性队列中.
主要方法:
- 利用了英国生物库数据 (N=178,711) 与2009-2012年24小时的饮食回忆.
- 排除了先前存在的IBS,乳病,炎症性肠病或癌症的参与者.
- 采用考克斯的比例危险模型来评估UPF百分比 (NOVA分类) 和发生IBS之间的关系,平均随访时间为11.3年.
主要成果:
- 10%的UPF消费增加与8%更高的IBS发展风险相关 (HR,1.08;95% CI,1.04-1.12).
- 在UPF消费的最高四分位数显示,与最低四分位数相比,发生IBS的风险显著增加 (HR,1.19;95% CI,1.07-1.33).
- 观察到一种显著的剂量-反应关系,在亚组分析中发现一致的结果,除了从未/以前饮酒组.
结论:
- 更高的超加工食品消费显然与发生刺激性肠综合征的风险增加有关.
- 该研究证实了显著的剂量反应关系,强调UPFs作为IBS的潜在饮食风险因素.
相关概念视频
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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The pathogenesis of IBS involves a complex interplay of the following factors:
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