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对药品片的喷墨式3D打印下降动态的数值研究

Tanu Mehta¹, Hossain Aziz¹, Koyel Sen¹

¹Department of Pharmaceutical Sciences, University of Connecticut, USA.

International journal of pharmaceutics

|March 24, 2024

概括

计算流体动力学 (CFD) 建模精确模拟喷墨3D打印滴形成. 这项研究验证了CFD通过分析流体特性和滴水特性来优化制药印刷工艺.

科学领域:

制药工程制药工程
材料科学材料科学材料科学
计算科学计算科学

背景情况:

3D打印在制药制造中提供了优势,包括个性化药物和成本效益.
基于喷墨的3D打印正在获得吸引力,FDA批准的Spritam®突出了这一点.
精确控制油墨/粘合剂喷射动态对于3D打印效率至关重要.

研究的目的:

用计算流体动力学 (CFD) 来研究基于喷墨的3D打印中的滴形成过程.
分析油墨特性对压电和热打印头滴落特征的影响.
为验证CFD模型与用于喷墨印刷应用的实验数据进行验证.

主要方法:

使用计算流体动力学 (CFD) 与流体体积 (VOF) 方法来建模滴形成.
使用ANSYS-Fluent软件用于CFD模型开发.
通过实验验证了CFD模型,使用下降观察器设置来记录下降的进展和速度.

主要成果:

评估了水,富士电影模型液体和Amitriptyline溶液作为油墨配方.
检查了墨水特性 (表面张力,粘度,密度) 对滴量,直径和速度的影响.
在模拟和实验数据之间实现了对下降体积和速度的良好一致.

结论:

CFD建模,特别是VOF方法,是模拟基于喷墨3D打印滴形成的可靠工具.
该研究提供了一种有效的方法,用于优化药品3D打印中的油墨配方和打印头设计.
了解流体动力学是提高3D打印药物的精度和效率的关键.

关键词:

通过3D打印打印3D打印.在 CFD 交易中,我们可以看到 CFD.流体动力学流体动力学喷墨印刷是一种喷墨印刷.这就是VOF VOF.

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