布拉斯托西斯特种的遗传特征. 在来自中国河北省的牛群中
Yuxin Sun1, Huizhu Nan1, Chao Zhang1
1Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Collaborative Innovation Center for Eco-Environment, Hebei Key Laboratory of Molecular and Cellular Biology, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, China.
Microbial pathogenesis
|March 24, 2024
概括
胚胎囊 sp. 的情况. 在中国感染牛,患病率为12.60%. 发现了7种亚型,表明牛群的遗传多样性很大. 这项研究强调了寄生虫.
科学领域:
- 兽医寄生虫学 兽医寄生虫学
- 分子流行病学分子流行病学
- 食物传播的病原体
背景情况:
- 胚胎囊 sp. 的情况. 是一种动物性原生动物寄生虫,与各种人类和动物胃肠道疾病有关.
- 了解胚胎囊菌种的情况. 牲畜中的感染动态对于公共卫生和动物福利至关重要.
- 关于Blastocystis sp.的流行率和遗传多样性的数据有限. 在中国的牛群中.
研究的目的:
- 确定Blastocystis sp.的流行率和遗传多样性 在来自中国河北省的牛中.
- 为了确定Blastocystis sp.的亚型. 在被调查的牛群中流通.
- 分析影响Blastocystis sp. 的因素. 牛群中的感染率.
主要方法:
- 从河北省11个城市收集和分析了2746个牛便样本.
- 聚合酶连锁反应 (PCR) 向胚胎细胞菌种. 用于检测的条形码基因.
- 使用MEGA,PhyloSuite和PopART进行的遗传学分析,以确定亚型,遗传距离和多样性指数.
主要成果:
- 在Blastocystis sp.的流行率为12.60% (346/2746). 在牛群中观察到感染.
- 较高的感染率与河北南部,一年以下的牛,密集农业和乳品种相关.
- 确定了七种亚型 (ST1,ST2,ST5,ST10,ST14,ST21,ST26),其中ST10和ST14占主导地位;记录了高核酸 (0.07749) 和单核型 (0.946) 的多样性.
结论:
- 这项研究提供了关于Blastocystis sp.的第一个全面的流行病学数据. 在中国河北省的牛群中.
- 在Blastocystis sp.的显著遗传多样性. 在牛群中存在,特定的亚型更为普遍.
- 诸如地区,年龄和农业实践等因素影响了Blastocystis sp. 牛群中的感染率,需要有针对性的控制策略.
相关概念视频
Pleiotropy
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Transgenic Organisms
Overview
X-linked Traits
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
Genetic Drift
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
Incomplete Dominance
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
X-linked Traits
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.


