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内皮葡萄糖损伤的生物标志物与复苏的败血症休克患者的微血管功能障碍有关

Nazir Soubihe Neto¹, Marcela Curci Vieira de Almeida¹, Helton de Oliveira Couto¹

¹Division of Emergency Medicine, Department of Internal Medicine, Ribeirão Preto School of Medicine, São Paulo University (USP), Ribeirão Preto, SP, Brazil.

Microvascular research

|March 24, 2024

概括

生物标志物,如合成甘-1 (SDC-1),可溶性CD44 (CD44s),血栓模块素 (TBML) 和糖氨基甘 (GAG) 表明内皮糖核损伤. 这些标记物与败血性休克患者的微血管功能障碍有关.

科学领域:

关键护理医学关键护理医学
血管生物学血管生物学
生物标志物发现发现

背景情况:

微血管功能障碍是感染性休克期间器官损伤的关键因素.
内皮糖 (eGC) 损伤与微循环受损有关.
评估eGC损伤生物标志物可以揭示与微血管功能障碍的关联.

研究的目的:

研究eGC损伤生物标志物和微血管功能障碍之间的关系.
为了评估合成甘-1 (SDC-1),可溶性CD44 (CD44s),氨酸 (HYAL),硫酸糖氨基甘 (GAGs) 和血栓模块素 (TBML) 的水平.
为了将这些生物标志物与复苏的败血症休克患者的微血管功能相关联.

主要方法:

一项横截面研究,将31名复苏的败血症休克患者与20名健康对照人进行比较.
在血液和尿液中测量了eGC损伤生物标志物 (SDC-1,CD44s,HYAL,GAGs,TBML).
使用舌下视频毛囊镜 (GlycoCheckTM) 评估微循环,以确定透的血管密度 (PVD),透的边界区域 (PBR) 和微血管健康评分 (MVHS).

主要成果:

SDC-1,CD44s,TBML和GAG水平在患有微血管功能受损 (低MVHS) 的败血症患者中显着更高.
这些生物标志物与PVD (<10μm) 和MVHS等受损的微血管参数存在相关性.
高水平的SDC-1,CD44s,TBML和GAG表明eGC损伤,并与较差的微循环有关.

结论:

SDC-1,CD44s,TBML和GAG与复苏性败血症休克中微血管功能受损有关.
这些生物标志物可以作为内皮糖损伤和微循环障碍的指标.
进一步的研究可以探索它们在败血症冲击管理中的预后价值.

关键词:

内细胞的葡萄糖.微血管功能障碍是什么败血症的冲击是一个令人震惊的结果.辛德肯-1-1是什么意思?

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