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Updated: Jun 30, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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瘤抑制剂NF2通过直接相互作用调节TEAD4稳定性和Hippo信号传递中的活性

Mengying Wu1, Liqiao Hu1, Lingli He2

  • 1Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.

The Journal of biological chemistry
|March 24, 2024
PubMed
概括

瘤抑制剂NF2直接结合并抑制TEAD4,这是Hippo通路中的关键转录因子. 这种相互作用使TEAD4不稳定,抑制细胞增殖,并揭示了一种新的瘤抑制机制.

关键词:
河马的路径 河马的路径NF2 NF2 是一个字母.在 TEAD4 的工作中,棕细胞代谢的发生蛋白质 - 蛋白质相互作用这是一种瘤抑制剂.

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