由西格玛-1受体对抗剂直接抑制GIRK通道的结构决定因素

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Updated: Jun 30, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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Chang Liu1, I-Shan Chen2, Michihiro Tateyama1

  • 1Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan; Program of Physiological Sciences, Field of Life Science, Department of Advanced Studies, SOKENDAI (The Graduate University for Advanced Studies), Hayama, Japan.

The Journal of biological chemistry
|March 24, 2024
PubMed
概括

BD1047二胺直接抑制G蛋白门内向整流器K+ (GIRK) 通道,特别是GIRK4,独立于西格玛-1受体活性. 这揭示了一个新的GIRK通道抑制剂和GIRK4相关疾病的潜在治疗点.

关键词:
BD104747 这是一本书.吉尔克·吉尔克 (GIRK) 是一个这是一种S1R抗剂.抑制抑制抑制的抑制作用结构决定因素 结构决定因素

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