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位于核中的帕尔瓦胺神经元调节叶发作在叶发作中的发作

Tong Jiang¹, Shuyu Liang¹, Xiaohan Zhang¹

¹Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.

Neurobiology of disease

|March 24, 2024

概括

位于核中的帕尔瓦胺神经元可以控制叶 (TLE) 发作. 激活这些神经元可以减少发作的频率和持续时间,为提供新的治疗点.

科学领域:

神经科学是一个神经科学.
发病学 (Epileptology) 是一个专业的学科.
分子生物学分子生物学

背景情况:

核 (NAc),特别是它的外,与叶 (TLE) 病变发生有关.
在TLE中NAc外内的帕瓦胺 (PV) GABAergic神经元的特定作用仍然在很大程度上是未知的.

研究的目的:

为了研究TLE中NAc外中的PV神经元的功能.
探索NAc-shell-hippocampus电路在调节TLE发作中的参与.

主要方法:

在动物中使用海马内酸给药诱导了一种TLE模型.
利用化学遗传学来激活或抑制NAc外PV神经元.
采用Ruby病毒追踪来识别NAc外PV神经元的投射目标.

主要成果:

在TLE模型中,NAc外PV神经元的化学遗传激活显著减少了焦点发作 (FSs) 和二次通用发作 (sGSs).
抑制NAc外PV神经元加剧了活动.
红宝石病毒映射显示了NAc外到腹部和背部海马的投射.
激活NAc-海马体PV投射纤维减轻了发作,而抑制没有影响.

结论:

在NAc外中的PV神经元在调节TLE发作中起着至关重要的作用.
连接NAc外和海马的远程电路参与了这种调制.
这些发现确定NAc-海马体PV电路是TLE的潜在治疗标.

关键词:

神经电路中的神经回路.核积累的中心 (nucleus accumbens).帕尔瓦胺神经元的神经元时间叶发作时间叶.在海马体内,海马体

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