西藏医学长丹片对通过MAPK通路的慢性阻塞性肺病的影响
Yulin Feng1, Pengfei Qin1, Rong Wang1
1State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Journal of ethnopharmacology
|March 24, 2024
概括
长丹片 (LDZK) 通过减少炎症和改善呼吸功能,对慢性阻塞性肺病 (COPD) 具有治疗作用. 这种西藏医学配方在高剂量下是安全的,向治疗慢性炎症的MAPK通路.
科学领域:
- 药理学和传统医学的医学.
- 呼吸系统疾病研究 呼吸系统疾病研究
背景情况:
- 龙丹药片 (LDZK) 是一种西藏药物,用于治疗支气管炎和喘等呼吸道疾病.
- 现有的具有抗炎功能的传统中医配方被用作补充性COPD疗法.
- 此前还没有评估LDZK的特定抗COPD作用.
研究的目的:
- 为了确定LDZK中主要的生物活性化合物.
- 研究LDZK对慢性阻塞性肺病 (COPD) 的治疗作用.
- 阐明LDZK在COPD中的作用的基本机制.
主要方法:
- 使用高分辨率质谱测量的LDZK的化学组成.
- 在LPS-papain诱导的COPD小鼠模型和LPS激活的A549细胞中评估的治疗效果.
- 通过在老鼠中进行的急性口服毒性测试来评估安全性.
- 机制预测采用了网络药理学和西方斑点分析.
主要成果:
- LDZK含有45种主要化合物,并且在COPD小鼠中显著改善了呼吸功能.
- LDZK减少了肺组织中的炎症细胞数量和细胞因子水平,并保护了A549细胞免受LPS诱导的损伤.
- 网络药理学和西部斑点表明LDZK通过抑制p38/ERK/JNK酸化来调节MAPK通路.
结论:
- 通过调节MAPK信号通路,LDZK对COPD表现出显著的治疗效果.
- 这些发现表明LDZK的潜力作为一种辅助疗法,用于控制COPD的慢性炎症.
- LDZK具有良好的安全性,即使剂量远高于临床使用.
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