在适应性免疫反应中,Ca2+微域的重要性
1The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Biochimica et biophysica acta. Molecular cell research
|March 24, 2024
概括
信号传递对T细胞免疫非常重要. 本综述强调了依附和T细胞受体刺激的微域,这些微域对于T细胞激活和免疫反应至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 信号传递对T细胞效应器功能,如增殖,分化,细胞因子分泌和细胞毒性至关重要.
- 在T细胞中 (Ca2+) 的失调与自身免疫性疾病,炎症和免疫缺陷有关.
- 局部化的Ca2+微域,由细胞外矩阵蛋白粘附和T细胞受体 (TCR) 刺激触发,是T细胞激活的关键早期信号.
研究的目的:
- 审查了解依赖粘附的Ca2+微域 (ADCM) 和T细胞受体刺激的Ca2+微域 (TDCM) 的最新进展.
- 探索由这些微域所影响的下游信号通路.
- 确定调节T细胞反应的潜在治疗点.
主要方法:
- 文献综述侧重于T细胞内信号传递的最新研究.
- 在T细胞激活前和期间调查Ca2+微域的研究分析.
- 对Ca2+微域下游的信号级联的检查.
主要成果:
- 依赖粘附的Ca2+微域 (ADCM) 即使没有T细胞受体 (TCR) 刺激,也起作用.
- 在几秒钟内,TCR刺激会唤起初始的Ca2+微域 (TDCM).
- 这些微域对于微调T细胞激活和适应性免疫是至关重要的.
结论:
- 微域,无论是依赖粘附还是TCR刺激,都是T细胞激活的关键调节者.
- 了解这些微域为人们提供了关于免疫反应和自身免疫状况的见解.
- 准Ca2+信号通路为与免疫相关的疾病提供了治疗机会.
更多相关视频
10:01Analysis of T-cell Receptor-Induced Calcium Influx in Primary Murine T-cells by Full Spectrum Flow Cytometry
Published on: December 16, 2022
4.0K
08:01Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions
Published on: January 19, 2024
1.3K
相关概念视频
Cells of the Adaptive Immune Response
984
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
984
Calmodulin-dependent Signaling
5.1K
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
5.1K
Immunoglobulin-like Cell Adhesion Molecules
3.3K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.3K
Membrane Domains
5.4K
The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
5.4K
Antigens Involved in Adaptive Immunity
489
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
489
Cell-mediated Immune Responses
68.2K
Overview
68.2K
